Using the gas pedal analogy explain the impact on the cell cycle of one mutated tumor suppressor gene allele versus two mutated tumor

Using the gas pedal analogy explain the impact on the cell cycle of one mutated tumor suppressor gene allele versus two mutated tumor suppressor alleles

Answers

Using the gas pedal analogy, the proto-oncogene would be an accelerator since they promote cell division and deregulate apoptosis, while tumor suppressor would be the brakes since they constrain the progress of the cell cycle and induce cell apoptosis. An oncogene is, therefore, when the accelerator is stuck in down position and the brakes are not working.

Proto oncogene are normal genes which are involved in cell growth and proliferation while the oncogenes are genes which have the potential to become cancerous. During cell division, proto oncogenes are strictly regulated, the cell division proceed appropriately and the division is terminated when the cell division is over. The cell division of the oncogenes on the other hand are not regulated, they continue dividing indefinitely.
 Using the gas pedal analogy, for the proto oncogenes,it will be GO, GO, GO, STOP. For the oncogenes, it will be GO GO GO GO GO GO [The 'GO' continues indefinitely].

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